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· signal transducer and activator of transcription 3 (stat3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, … · here we found that icb reprograms the interplay between the stat3 and stat5 transcriptional pathways in dendritic cells, thereby activating t cell immunity and enabling icb … While stat3 plays an … These inhibitors are being investigated for … Report that hypoxia and inflammatory cytokines activate the stat3/integrin β3 axis, promoting stress tolerance and accelerating pancreatic cancer … The stat3 gene is part of a family known as the stat genes. Diseases associated with stat3 include hyper-ige syndrome 1, autosomal dominant, with … · stat3 (signal transducer and activator of transcription 3) is a protein coding gene. Stat3 is a member of the stat protein family. While stat3 plays an essential role in … In response to cytokines and growth factors, stat3 is phosphorylated by receptor-associated janus kinases (jak), forms homo- or heterodimers, … Abstract signal transducer and activator of transcription 3 (stat3) is a critical transcription factor involved in multiple physiological and pathological processes. Signal transducer and activator of transcription 3 (stat3) is a critical transcription factor involved in multiple physiological and pathological processes. Learn about this gene and related health conditions. Stat3 inhibitors represent a developing area in medical research, focusing on a protein called signal transducer and activator of transcription 3. · campos and shepard et al.