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[10] mediators include leukotrienes, histamines, prostaglandin, and tryptase. Learn how to identify and alleviate symptoms of mast cell activation syndrome (mcas). Mast cell activation syndrome (mcas) happens with repeated symptoms of anaphylaxis – allergic symptoms such as hives, swelling, low blood pressure, difficulty breathing and severe diarrhea. Mast cell activation syndrome (mcas) is increasingly appearing to be the bulk of the iceberg of mast cell activation diseases (mcad), all of which share the common theme of inappropriate mast cell activation. It causes severe symptoms and can lead to life-threatening anaphylaxis. Mcas is condition that involves the activation of mast cells, a type of immune cell that plays a role in the bodys response to allergens and other triggers. · inflammation flares can be confusing. · mast cell activation syndrome, also called mcas or mast cell activation disorder, is a condition that causes mast cells to release high amounts of chemicals into your body. · mast cell activation syndrome (mcas) is when your mast cells overreact with no known trigger. Mast cell activation syndrome (mcas) causes a person to have repeated severe allergy symptoms affecting several body systems. In mcas, mast cells mistakenly release too many chemical agents, resulting in symptoms in the skin, gastrointestinal tract, heart, respiratory, and neurologic systems. Mast cell activation syndrome (mcas) is the most common type of mast cell disease. This diagnosis has been attached to multiple medical conditions not intended as part of the diagnosis. Symptoms of mcas are caused by excessive chemical mediators released by mast cells.