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· gefurulimab, an investigational complement c5 inhibitor, is a novel dual-binding nanobody optimised for subcutaneous self-administration in development as a treatment for … The medication is designed to provide sustained disease control without the need for in-clinic … · “a once-weekly, self-administered c5 treatment option would offer patients greater convenience and independence in managing their condition, empowering them to have more … · astrazeneca’s rare disease division, alexion, is developing gefurulimab, a once-weekly, self-administered subcutaneous c5 inhibitor. To evaluate subcutaneous zilucoplan in adults with acetylcholine receptor autoantibody-positive generalised myasthenia gravis (gmg) who switched from intravenous … · it targets complement c5 to prevent terminal complement cascade activation. · the pharmaceutical giant sees the drug, gefurulimab, as a more convenient, self-administered alternative to the infused medicines it currently sells for myasthenia gravis. The product can … · the phase iii prevail trial testing astrazeneca’s complement c5 inhibitor gefurulimab was positive in patients with generalized myasthenia gravis (gmg). · astrazenecas gefurulimab, a once-weekly, self-administered c5 inhibitor, achieved statistically significant and clinically meaningful improvements in its phase iii prevail trial for … · a once-weekly, self-administered c5 treatment option would offer patients greater convenience and independence in managing their condition, empowering them to have more … The prevail study assessed gefurulimab’s …